new tools in synthesis	Synlett 1999; 1999: 366-374 DOI: 10.1055/s-1999-2612
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Discovery of New Multi Component Reactions with Combinatorial Methods
Lutz Weber*, Katrin Illgen, Michael Almstetter
*Morphochem AG, Am Klopferspitz 19, D-82152 Martinsried, Germany

The discovery of novel chemical reactions or reaction sequences that are able to generate useful chemical products may be regarded as the heart of organic chemistry. We present here concepts and methods on how to find and explore new multi component reactions, especially with automated combinatorial methods. This "combinatorial reaction finding" provides also a powerful tool to the understanding of the rules of organic chemistry, especially structure-reactivity relationships.

multi component reaction - combinatorial chemistry - synthetic strategy - reaction design