Letter	Planta Med 2001; 67: 292-294 DOI: 10.1055/s-2001-11998
© Georg Thieme Verlag Stuttgart · New York
On the Absolute Configuration of Matricin
Susanne Goeters1, Peter Imming1,*, Gregor Pawlitzki2, Bernd Hempel3
1 Institut für Pharmazeutische Chemie der Philipps-Universität Marburg, Marburg, Germany 2 Kekulé-Institut für Organische Chemie und Biochemie, Bonn, Germany 3 Robugen GmbH, Esslingen, Germany

Abstract

The assignment of the absolute configuration of matricin rests on indirect evidence. On the basis of synthetic, NMR and CD studies with its decomposition product, chamazulene carboxylic acid, we were able to firmly establish the accepted 3S,3aR,4S,9R,9aS,9bS configuration of matricin.