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| PAPER | Synthesis 2002: 0099-0103
DOI: 10.1055/s-2002-19297 |
© Georg Thieme Verlag Stuttgart · New York
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A Convenient Method for the Synthesis of Terminal (E)-1,3-Dienes
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| Yong Wang, F. G. West* |
Department of Chemistry, University of Utah, 315 S. 1400 East, Rm. 2020, Salt Lake City, UT 84112-0850, USA
Fax: +1(801)5818433; e-Mail: west@chemistry.utah.edu;
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Received
22 August 2001 |
Abstract
Lithiated allylic phosphonates undergo efficient olefination reactions with a variety of aldehydes in the presence of HMPA to give terminal 1,3-dienes with high selectivity for the E-isomer. This method is general and procedurally simple. Key words
aldehydes - alkenation - phosphorus - Wittig reactions - ylides
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