PAPER	Synthesis 2002: 0075-0078 DOI: 10.1055/s-2002-19308
© Georg Thieme Verlag Stuttgart · New York
Microwave Assisted Synthesis of 1,5-Disubstituted Hydantoins and Thiohydantoins in Solvent-Free Conditions
Satya Paul*a, Mukta Guptaa, Rajive Guptaa, André Loupyb
a Department of Chemistry, University of Jammu, Jammu-180 006, India Fax: +91(191)505086; e-Mail: paul7@rediffmail.com; b Laboratoire des Réactions Sélectives sur Supports, CNRS UMR 8615, Université Paris-Sud, 91405, Orsay, France Fax: +33(169)154679; e-Mail: aloupy@icmo.u-psud.fr;
Received 28 June 2001

Abstract

1,5-Disubstituted hydantoins/thiohydantoins 3a-p have been synthesized in 81-95% yield by a microwave-promoted solvent-free condensation of arylglyoxals 1 and phenylurea/thiourea 2 using PPE as a reaction mediator. This method can be extended towards the parallel synthesis of 3. The workup is simple and involves treatment with ice-cold water.

Key words

arylglyoxals - solvent-free conditions - polyphosphoric ester (PPE) - microwave activation - hydantoins