PAPER	Synthesis 2002: 0203-0206 DOI: 10.1055/s-2002-19803
© Georg Thieme Verlag Stuttgart · New York
One-pot Conversion of t-Butyl Carbamates to Amides with Acyl Halide-Methanol Mixtures
Abdesslame Nazih*, Denis Heissler
Université Louis Pasteur et Centre National de la Recherche Scientifique, Institut de Chimie, BP 296, 67008 Strasbourg, France Fax: +33(3)90241765; e-Mail: nazih@chimie.u-strasbg.fr;
Received 13 July 2001

Abstract

Acyl halide-methanol mixtures are efficient reagents for the one-pot transformation of t-butyl carbamates into amides. This transformation can be carried out in the presence of a benzyloxycarbonyl group.

Key words

carbamates - acylations - amides - chemoselectivity - protecting groups