PAPER	Synthesis 2002: 0466-0470 DOI: 10.1055/s-2002-20956
© Georg Thieme Verlag Stuttgart · New York
Catalysis of the Biginelli Reaction by Ferric and Nickel Chloride Hexahydrates. One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones
Jun Lu*, Yinjuan Bai
Department of Chemistry, Northwest University, Shaanxi Province Key Laboratory of Physico-inorganic Chemistry. Xi'an, Shaanxi 710069, P. R. China e-Mail: lujunyue@hotmail.com;
Received 19 November 2001

Abstract

An efficient synthesis of 3,4-dihydropyrimidinones from the aldehyde, β-keto ester and urea in ethanol, using ferric chloride hexahydrate or nickel chloride hexahydrate as the catalyst, is described. Compared with the classical Biginelli reaction conditions, this new method has the advantage of excellent yields (53-97%) and short reaction time (4-5 hours).

Key words

Biginelli reaction - dihydropyrimidine-2(1H)-ones - nickel chloride hexahydrate - ferric chloride hexahydrate