SHORTPAPER	Synthesis 2002: 0720-0722 DOI: 10.1055/s-2002-25767
© Georg Thieme Verlag Stuttgart · New York
A General Procedure for the Synthesis of 2-Substituted Pyrimidine-5-Carboxylic Esters
Pavel Zhichkina, David J. Fairfax*a, Shane A. Eisenbeisb
a Albany Molecular Research Inc., 21 Corporate Circle, PO Box 15098, Albany, NY 12212, USA b Pfizer Global Research and Development, Groton Laboratories, Pfizer Inc., Eastern Point Road, Groton, CT 06340, USA Fax: +1(518)4640289; e-Mail: DavidF@albmolecular.com;
Received 6 November 2001

Abstract

A method for the synthesis of 2-substituted pyrimidine-5-carboxylic esters is described. The sodium salt of 3,3-dimethoxy-2-methoxycarbonylpropen-1-ol (3) has been found to react with a variety of amidinium salts to afford the corresponding 2-substituted pyrimidine-5-carboxylic esters.

Keywords

heterocycles - pyrimidines - condensation - amidinium salt - esters