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| PSP | Synthesis 2002: 1121-1123
DOI: 10.1055/s-2002-31969 |
© Georg Thieme Verlag Stuttgart · New York
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Reduction of Ethanethiol Esters to Aldehydes
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| Hidetoshi Tokuyama, Satoshi Yokoshima, Shao-Cheng Lin, Leping Li, Tohru Fukuyama* |
Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
e-Mail: fukuyama@mol.f.u-tokyo.ac.jp;
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Received
26 March 2002 |
Abstract
Reduction of ethanethiol esters of α-amino acids to α-amino aldehydes by triethylsilane and catalytic palladium-on-carbon is described. α-Amino aldehydes with Boc, Cbz, or Fmoc protection could be obtained without racemization in high yield. Key words
reductions - aldehydes - thiol esters - amino aldehydes
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