SHORTPAPER	Synthesis 2002: 1804-1806 DOI: 10.1055/s-2002-33906
© Georg Thieme Verlag Stuttgart · New York
Tetrabutylammonium Peroxydisulfate in Organic Synthesis; XIII. [1] A Simple and Highly Efficient One-Pot Synthesis of Nitriles by Nickel-Catalyzed Oxidation of Primary Alcohols with Tetrabutylammonium Peroxydisulfate
Fen-Er Chen*, Yong-Ye Li, Mei Xu, Hui-Qing Jia
Department of Chemistry, Fudan University, Shanghai 200433, P. R. China Fax: +86(21)65642021; e-Mail: rfchen@fudan.edu.cn;
Received 30 April 2002

Abstract

A facile one-pot method is presented for the synthesis of nitriles from the corresponding primary alcohols by nickel-catalyzed oxidation with tetrabutylammonium peroxydisulfate in the presence of ammonium hydrogen carbonate under basic aqueous conditions. This convenient synthetic method provides an easy and simple access to various aliphatic, aromatic and heterocyclic nitriles in excellent yields with very high purity.

Key words

tetrabutylammonium peroxydisulfate - nitriles - primary alcohols - oxidation

1

Part XII: Chen, F. E.; Lu Y. W.; He, Y. P.; Luo, Y. F.; Yan, M. G. Synth. Commun. 2002, in press.