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| LETTER | Synlett 2003: 0414-0416
DOI: 10.1055/s-2003-37119 |
© Georg Thieme Verlag Stuttgart · New York
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An Effective Synthesis of α-Cyanoenamines
by Peterson Olefination
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| Waldemar
Adam, Claudio M.
Ortega-Schulte* |
Institute of Organic Chemistry, University of Würzburg, Am Hubland,
97074 Würzburg, Germany
Fax: +49(931)8884756; e-Mail: adam@chemie.uni-wuerzburg.de;
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Received
29 November 2002 |
Abstract
A convenient and gentle method for the synthesis of α-cyanoenamines
based on the Peterson olefination has been developed. For these
sensitive, highly functionalized olefins, the present method is
superior to the Horner-Emmons condensation, as manifested
by the higher yields and broader scope. Key words
α-Cyanoenamines - Peterson olefination - Horner-Emmons
condensation
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