 |
| LETTER | Synlett 2003: 2321-2324
DOI: 10.1055/s-2003-42118 |
© Georg Thieme Verlag Stuttgart · New York
|
 |
A Novel Catalytic Three-Component Synthesis (Kabachnick-Fields Reaction) of α-Aminophosphonates from Ketones
|
| Elena D. Matveeva*, Tatyana A. Podrugina, Elena V. Tishkovskaya, Larisa G. Tomilova, Nikolay S. Zefirov* |
Department of Chemistry, Moscow Lomonosov University, Moscow, Russia
Fax: +7(95)9390290; e-Mail: edmatveeva@mail.ru; e-Mail: zefirov@org.chem.msu.ru;
|
|
Received
11 July 2003 |
Abstract
A novel and highly convenient catalytic variant of the synthesis of α-aminophosphonates on basis of the Kabachnik-Fields reaction [three-component reaction of ketones, diethylphosphite and either benzylamine (series a) of ammonium carbonate (series b)] in the presence of tetra-tert-butylphthalocyanines has been developed. This method affords α-aminophosphonates in acceptable yields for various ketones, including cyclic, sterically hindered and cage ketones. The unsubstituted α-aminophosphonic acids were also obtained from the corresponding esters of series b. Key words
α-aminophosphonates - catalysis - tetra-tert-butylphthalocyanines - ketones - α-aminophosphonic acids
| |
