PAPER	Synthesis 2003: 2777-2780   DOI: 10.1055/s-2003-42488
© Georg Thieme Verlag Stuttgart · New York
Efficient Conversions of Carboxylic Acids into O-Alkyl, N-Alkyl and O,N-Dialkylhydroxamic Acids
Alan R. Katritzky*, Nataliya Kirichenko, Boris V. Rogovoy
Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA Fax: +1(352)3929199; e-Mail: Katritzky@chem.ufl.edu;
Received 8 May 2003

Abstract

Carboxylic acids were conveniently converted into unsubstituted, N-alkyl-, O-alkyl-, and O,N-dialkylhydroxamic acids via acylbenzotriazole intermediates. The ready availability of the reagents, mild conditions, and easy handling of the intermediates are advantageous.

Key words

hydroxamic acid - Weinreb amide - carboxylic acids - regioselectivity - nucleophilic