PAPER	Synthesis 2004: 59-62   DOI: 10.1055/s-2003-44346
© Georg Thieme Verlag Stuttgart · New York
Further Improvements of the Synthesis of Alkynes from Aldehydes
Gerald J. Roth*, Bernd Liepold, Stephan G. Müller, Hans Jürgen Bestmann
Institut für Organische Chemie der Universität Erlangen-Nürnberg, Henkestraße 42, 91054 Erlangen, Germany Fax: +49(7351)834404; e-Mail: gerald.roth@bc.boehringer-ingelheim.com;
Received 19 August 2003

Abstract

A highly convenient way to perform the synthesis of alkynes from aldehydes is reported. The procedure utilizes a new in situ preparation of dimethyldiazomethylphosphonate. As a consequence a commercially available reagent can now be used, circumventing a disadvantage of earlier protocols. The easy one-pot procedure avoids the use of strong bases, low temperatures and inert gas techniques.

Key words

alkynes - phosphonates - rearrangements