PAPER	Synthesis 2004: 1434-1438   DOI: 10.1055/s-2004-822366
© Georg Thieme Verlag Stuttgart · New York
Efficient Preparation of Optically Pure C2-Symmetrical Cyclic Amines for Chiral Auxiliary
Mitsuo Sato, Yasuhiko Gunji, Taketo Ikeno, Tohru Yamada*
Department of Chemistry, Faculty of Science and Technology, Keio University, Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan Fax: +81(45)5661716; e-Mail: yamada@chem.keio.ac.jp;
Received 2 January 2004

Abstract

Optically pure C₂-symmetrical amines were efficiently synthesized from the corresponding diols obtained from the enantioselective borohydride reduction of the diketones catalyzed by the optically active b-ketoiminato cobalt(II) complex.

Key words

asymmetric reduction - chiral diols - cyclic chiral amines - borohydride - cobalt