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| PAPER | Synthesis 2004: 1589-1594
DOI: 10.1055/s-2004-822391 |
© Georg Thieme Verlag Stuttgart · New York
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‘One-Pot' Synthesis of Chiral N-Protected α-Amino Acid-Derived 1,2,4-Oxadiazoles
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| Antonio L. Braga*a, Diogo S. Lüdtkea, Eduardo E. Albertoa, Luciano Dornelles*b, Wolmar A. Severo Filhob, Valeriano A. Corbellinib, Daiane M. Rosab, Ricardo S. Schwabb |
a Departamento de Química, Universidade Federal de Santa Maria, 97105-900, Santa Maria, RS, Brazil
Fax: +55(55)2208031; e-Mail: albraga@quimica.ufsm.br;
b Departamento de Química e Física, Universidade de Santa Cruz do Sul, 96815-900, Santa Cruz do Sul, RS, Brazil
e-Mail: luciano@unisc.br;
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Received
9 January 2004 |
Abstract
A series of α-amino acid-derived 1,2,4-oxadiazoles have been synthesized via an easy, inexpensive and one-pot protocol. The heterocycles were obtained in good yields and in relatively short reaction times. Key words
amino acids - oxadiazoles - heterocycles
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