SHORTPAPER	Synthesis 2004: 1741-1743   DOI: 10.1055/s-2004-829148
© Georg Thieme Verlag Stuttgart · New York
A Mild and Efficient Oxidative Deprotection of THP Ethers with NBS in the Presence of β-Cyclodextrin in Water
M. Narender, M. Somi Reddy, K. Rama Rao*
Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad-500 007, India e-Mail: drkrrao@yahoo.com;
Received 9 February 2004

Abstract

An efficient and user-friendly procedure has been developed for the oxidative deprotection of tetrahydropyranyl (THP) ethers with N-bromosuccinimide (NBS) using β-cyclodextrin (β-CD) in water. A series of tetrahydropyranyl ethers were oxidatively deprotected at room temperature in impressive yields.

Key Words

oxidative deprotection - tetrahydropyranyl ethers - N-bromosuccinimide - β-cyclodextrin - water