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| PAPER | Synthesis 2004: 2485-2492
DOI: 10.1055/s-2004-831250 |
© Georg Thieme Verlag Stuttgart · New York
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TFFH as an Excellent Reagent for Acylation of Alcohols, Thiols and Dithiocarbamates
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| Michael Pittelkowa, Fadhil S. Kamounahb, Ulrik Boasa, Brian Pedersena, Jørn B. Christensen*a |
a Department of Chemistry, University of Copenhagen, Universitetsparken 5, 2100 Copenhagen, Denmark
Fax: +4535322012; e-Mail: jbc@kiku.dk;
b Department of Lifescience and Chemistry, Roskilde University, Universitetsvej 1, Postal Box 260, 4000 Roskilde, Denmark
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Received
17 May 2004 |
Abstract
A convenient and easy procedure to synthesize esters and thioesters from the corresponding carboxylic acid using TFFH as the coupling reagent is described. The preparation of N-acyl-dithiocarbamates from carboxylic acids and 1,3-thiazolidine-2-thione with TFFH as the coupling reagent is also described. Key words
esterification - coupling reagents - acylations - esters - thioesters - thioacids - dithiocarbamates
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