Original Clinical	Horm Metab Res 2005; 37: 242-245 DOI: 10.1055/s-2005-861410
© Georg Thieme Verlag KG Stuttgart · New York
Transient Increase of Plasma Ghrelin after Laparoscopic Adjustable Gastric Banding in Morbid Obesity
L.  M.  Mariani1, A.  Fusco1, M.  Turriziani1, A.  Veneziani3, M.  A.  Marini1, A.  de Lorenzo2, A.  Bertoli1
1 Department of Internal Medicine, Tor Vergata University of Rome, Italy 2 Department of Neuroscience, Tor Vergata University of Rome, Italy 3 Department of Surgery, Catholic University of Rome, Italy

Abstract

Ghrelin is a peptide hormone with orexigenic properties that is produced by the stomach. Ghrelin and leptin are thought to be the main regulators of appetite and body weight. The present study was aimed at evaluating the effect of weight reduction after laparoscopic adjustable gastric banding (LAGB) on metabolic parameters and energy balance regulatory peptides. Patients were evaluated before and 6, 12, 24 or 36 months after the procedure, and a blood sample was obtained. Ghrelin rose 6 and 12 months after LABG, and then returned to near-baseline levels. In our study, the correlation between ghrelin and BMI was weak, but a strong significant correlation was maintained between leptin and BMI. We conclude that ghrelin is mainly stimulated by the negative caloric balance, and hypothesize that ghrelin is involved in maintaining a stable body weight, while leptin signals the body energy store; both hormones together are part of a more complex feedback mechanism.

Key words

Ghrelin - Leptin - Obesity - LAGB