 |
Original Clinical
| Horm Metab Res 2005; 37: 316-325
DOI: 10.1055/s-2005-861487 |
© Georg Thieme Verlag KG Stuttgart · New York |
| |
 |
Soy Protein Influences the Development of the Metabolic Syndrome in Male Obese ZDFxSHHF Rats |
| |
| J. Davis1,2, M. J. Iqbal1, J. Steinle2, J. Oitker2, D. A. Higginbotham1,2, R. G. Peterson3, W. J. Banz1,2 |
1 Department of Animal Science, Food & Nutrition, Southern Illinois University, Carbondale, IL, USA
2 Department of Physiology, Southern Illinois University, Carbondale, IL, USA
3 Indiana University School of Medicine, Indianapolis, IN, USA |
Abstract
Previous investigations have demonstrated a marked effect of soy protein on the metabolic syndrome (MS). The purpose of this preliminary study was to identify the effects of soy-based diets on male obese ZDFxSHHF (fa/fa-cp/?) rats. Animals were randomly assigned to one of four diets: control, casein (C); low-isoflavone (LIS) soy protein; high-isoflavone (HIS) soy protein; or casein + rosiglitazone (CR). Physiological, biochemical, and molecular parameters were determined at sacrifice. Body weight (p < 0.01) and food intake (p < 0.05) were lower in LIS-fed rodents. Rosiglitazone-treated animals had higher body weight and adiposity (p < 0.05). LIS and CR groups exhibited better glycemic control (p < 0.05), but with a limited effect in rosiglitazone-treated animals. HIS fed rats had higher glucose and triacylglyceride levels (p < 0.01), and lower plasma insulin (p < 0.01). Renal function parameters with the exception of an increase in systolic blood pressure (p < 0.05) were all suppressed in the LIS group (p < 0.01). The CR group had twofold PPARα and PPARγ mRNA abundance (p < 0.01). LIS-fed animals also exhibited greater abundance of PPARγ mRNA (p < 0.001), and nearly threefold FAS and CPT-1 mRNA levels (p < 0.05). HIS-fed rats also had higher abundance of CPT-1 mRNA, as well as a lower abundance of ACC mRNA (p < 0.05). Soy-based diets, influenced by isoflavone content and distinct from rosiglitazone, improved several metabolic parameters in obese ZDFxSHHF rats.
Key words
Soy protein - Isoflavone content - Metabolic syndrome - Gene expression - ZDFxSHHF
| |
