SHORTPAPER	Synthesis 2005: 1231-1233   DOI: 10.1055/s-2005-865282
© Georg Thieme Verlag Stuttgart · New York
An Efficient and Practical Procedure for the Synthesis of 4-Substituted Coumarins
Surya K. De*, Richard A. Gibbs
Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy, Purdue Cancer Center, Purdue University, West Lafayette, IN 47907, USA Fax: +1(765)4941414; e-Mail: skd125@pharmacy.purdue.edu;
Received 19 October 2004

Abstract

BiCl₃ is used as an efficient catalyst in the Pechmann condensation reaction of phenols with β-keto esters leading to the formation of coumarin derivatives in excellent yields under solvent-free conditions.

Key words

phenols - β-keto ester - Pechmann reaction - bismuth(III) chloride - coumarin