PAPER	Synthesis 2005: 1326-1332   DOI: 10.1055/s-2005-865303
© Georg Thieme Verlag Stuttgart · New York
A Simple and Efficient Heterogeneous Procedure for Thioacetalization of Aldehydes and Ketones
Mohammed Hashmat Ali*, Maria Goretti Gomes
Chemistry Department, Southeast Missouri State University, Cape Girardeau, MO 63701, USA Fax: +1(573)9866433; e-Mail: mhali@semo.edu;
Received 13 July 2004

Abstract

A new procedure for the protection of aldehydes and ketones as thioacetals promoted by catalytic amount of p-toluenesulfonic acid and silica gel has been developed. This procedure offers versatility, short reaction time, excellent yield, good selectivity, and flexibility in terms of choice of solvent that can be utilized in this reaction. The procedure is easy to carry out and does not require aqueous work-up. A simple filtration followed by removal of solvent in most cases produces pure product.

Key words

thioacetal - silica gel - heterogeneous - ketones - aldehydes