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| PAPER | Synthesis 2005: 3541-3548
DOI: 10.1055/s-2005-916041 |
© Georg Thieme Verlag Stuttgart · New York
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A Convenient and Efficient One-Pot Synthesis of 3-Acylisoxazoles Using Iron(III) Salts
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| Ken-ichi Itoha, Hiroshi Sakamakia, Noriko Nakazatob, Atsuo Horiuchib, Ernst Hornb, C. Akira Horiuchi*b |
a College of Science and Technology, Nihon University, 7-24-1 Narashinodai Funabashi-shi, Chiba 274-8501, Japan
b Department of Chemistry, Rikkyo (St. Paul's) University, 3-34-1 Nishi-Ikebukuro, Toshima-ku Tokyo 171-8501, Japan
Fax: +81(3)39852397; e-Mail: horiuchi@rikkyo.ac.jp;
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Received
12 May 2005 |
Abstract
3-Acylisoxazoles were synthesized by the reaction of alkenes or alkynes with ketones (acetone or acetophenone), as both a reagent and the solvent, by three methods: iron(III) nitrate under reflux, iron(III) salt-nitrogen dioxide (NO2) at room temperature, and iron(III) nitrate under microwave irradiation (MW). Key words
alkenes - alkynes - ketones - iron(III) nitrate - 3-acylisoxazoles
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