Letter	Planta Med 2006; 72: 376-378 DOI: 10.1055/s-2005-916217
© Georg Thieme Verlag KG Stuttgart · New York
The Effects of Ginsenoside Re and its Metabolite, Ginsenoside Rh1, on 12-O-Tetradecanoylphorbol 13-acetate- and Oxazolone-Induced Mouse Dermatitis Models
Yong-Wook Shin1, Eun-Ah Bae1, Sung-Soo Kim2, Young-Chul Lee2, Boo-Young Lee3, Dong-Hyun Kim1
1 College of Pharmacy, Kyung Hee University, Seoul, Korea 2 Korea Food Research Institute, Seoungnam-Shi, Korea 3 Pochun Cha University, Seoungnam-Shi, Korea

Abstract

The effects of the main constituent ginsenoside Re in ginseng and its metabolite, ginsenoside Rh1, were investigated in 12-O-tetradecanoylphorbol 13-acetate (TPA)- and oxazolone-induced mouse ear dermatitis models. Ginsenoside Rh1 potently suppressed the TPA- and oxazolone-induced swellings as well as mRNA expression levels of cyclooxygenase-2, IL-1β and TNF-α, although these were only weakly inhibited by ginsenoside Re.

Abbreviations

TPA:12-O-tetradecanoilphorbol 13-acetate

COX:cyclooxygenase

TNF-α:tumor necrosis factor-α

IL-1β:interleukin-1β