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| PAPER | Synthesis 2005: 3229-3234
DOI: 10.1055/s-2005-918480 |
© Georg Thieme Verlag Stuttgart · New York
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Efficient Palladium-Catalysed Enamide Synthesis from Enol Triflates and Enol Tosylates
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| Michael C. Willis*a, Gareth N. Bracea, Ian P. Holmesb |
a Department of Chemistry, University of Bath, Bath, BA2 7AY, UK
b Discovery Research, GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, UK
Fax: +44(1225)386231; e-Mail: m.c.willis@bath.ac.uk;
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Received
19 August 2005 |
Abstract
Catalysts generated from Pd2(dba)3 and biphenyl ligands 4 and 7 efficiently promote the coupling of amides and carbamates with unactivated vinyl triflates and tosylates, to provide enamides in good to excellent yields. Key words
enamides - palladium - catalysis - enol triflates - enol tosylates
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