SHORTPAPER	Synthesis 2006: 224-226   DOI: 10.1055/s-2005-918507
© Georg Thieme Verlag Stuttgart · New York
Phosphorus Pentasulfide: A Mild and Versatile Reagent for the Preparation of Thioamides from Nitriles
Babak Kaboudin*, Dawood Elhamifar
Department of Chemistry, Institute for Advanced Studies in Basic Sciences (IASBS), Gava Zang, Zanjan 45195-1159, Iran Fax: +98(241)4249023; e-Mail: kaboudin@iasbs.ac.ir;
Received 19 July 2005

Abstract

A simple, efficient, and new method has been developed for the synthesis of thioamides from nitriles. The reaction of a variety of aromatic and aliphatic nitriles in the presence of phosphorus pentasulfide afforded the corresponding thioamides in high yields. This method is easy, rapid, and high-yielding for the synthesis of thioamides from nitriles.

Key words

thioamides - nitriles - phosphorus pentasulfide - phosphorodithioates - addition reactions