PAPER	Synthesis 2006: 451-454   DOI: 10.1055/s-2005-918519
© Georg Thieme Verlag Stuttgart · New York
Iodoxybenzoic Acid (IBX): An Efficient and Novel Oxidizing Agent for the Aromatization of 1,4-Dihydropyridines [1]
J. S. Yadav*, B. V. S. Reddy, A. K. Basak, G. Baishya, A. Venkat Narsaiah
Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500007, India Fax: yadavpub@iict.res.in; e-Mail: +91(40)27160512;
Received 7 July 2005

Abstract

Hantzsch 1,4-dihydropyridines undergo smooth aromatization catalyzed by iodoxybenzoic acid (IBX) to afford the corresponding pyridine derivatives in high yields. All the reactions were carried out in DMSO solvent at 80-85 °C for a period of two to four hours to complete conversion of the substrates.

Keywords

hypervalent iodine reagents - dihydropyridines - aromatization - DMSO - pyridine derivatives

1

IICT Communication No. 041107.