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| LETTER | Synlett 2006: 315-317
DOI: 10.1055/s-2005-923592 |
© Georg Thieme Verlag Stuttgart · New York
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Manganese-Promoted β-Elimination Reactions: Totally Stereoselective Synthesis of (E)-α,β-Unsaturated Esters
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| José M. Concellón*, Humberto Rodríguez-Solla, Vicente del Amo |
Dpto. Química Orgánica e Inorgánica, Universidad de Oviedo, C/ Julián Clavería 8, 33006, Oviedo, Spain
e-Mail: jmcg@fq.uniovi.es;
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Received
17 October 2005 |
Abstract
Stereoselective β-elimination of 2-bromo-3-hydroxyesters is achieved by using non-preactivated manganese and trimethylsilyl chloride, to yield (E)-α,β-unsaturated esters with total diastereoselectivity. Key words
alkenes - diastereoselectivity - esters - eliminations - manganese
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