Original Thoracic	Thorac cardiovasc Surg 2007; 55: 177-179 DOI: 10.1055/s-2006-924625
© Georg Thieme Verlag KG Stuttgart · New York
Isolated Lung Perfusion with Paclitaxel and Docetaxel: Comparison of the Early Effects on Pulmonary Physiology
S. Tanju1, B. Akpolat1, E. Senturk2, S. Ziyade1, A. Toker1, D. Yilmazbayhan3, A. Aydiner4, S. Dilege1
1 Thoracic Surgery, Istanbul Medical School, Istanbul University, Istanbul, Turkey 2 Anesthesiology, Istanbul Medical School, Istanbul University, Istanbul, Turkey 3 Pathology, Istanbul Medical School, Istanbul University, Istanbul, Turkey 4 Medical Oncology, Istanbul Medical School, Istanbul University, Istanbul, Turkey

Abstract

Background: This study was designed to compare the early effects of docetaxel and paclitaxel on pulmonary physiology after isolated lung perfusion. Methods: Rats underwent isolated left lung perfusion with docetaxel in group 1 (n = 5), paclitaxel in group 2 (n = 5), and 0.9 %NaCl in the control group (n = 5). Ventilation pressures, compliance of the lungs, blood gas analysis and histopathological results were compared between the groups. Results: In group 1 and group 2, the decrease in PaO₂ (p = 0.008) and increase in ventilation pressures were significantly higher than in the control group (p = 0.016). In group 2, pCO₂ retention was higher compared to the docetaxel perfusion group (p = 0.016). In the histochemical assessment, intra-alveolar hemorrhage and mononuclear cell infiltration were dense and perivascular edema was not present in group 1. In group 2, perivascular and intraalveolar edema were found to be dense. Conclusion: Perfusion by either of the chemotherapeutics resulted in an alteration of lung physiology in rat lungs. If isolated lung perfusion is administered using chemotherapeutics from the taxanes group, it is suggested that docetaxel could be the first choice for isolated lung perfusion.

Key words

thoracic surgery - isolated lung perfusion - taxanes