PAPER	Synthesis 2006: 1419-1422   DOI: 10.1055/s-2006-926421
© Georg Thieme Verlag Stuttgart · New York
(Bromodimethyl)sulfonium Bromide Catalyzed One-Pot Synthesis of α-Aminonitriles [1]
Biswanath Das*, R. Ramu, B. Ravikanth, K. Ravinder Reddy
Organic Chemistry Division I, Indian Institute of Chemical Technology, Hyderabad 500 007, India Fax: +91(40)7160512; e-Mail: biswanathdas@yahoo.com;
Received 7 September 2005

Abstract

A novel, simple and efficient one-pot synthesis of α-aminonitriles has been achieved by a three-component condensation of carbonyl compounds, amines and trimethylsilyl cyanide in the presence of (bromodimethyl)sulfonium bromide as a catalyst at room temperature. The products were obtained in high yields and in short reaction times.

Keywords

α-aminonitriles - carbonyl compounds - amines - trimethylsilyl cyanide - (bromodimethyl)sulfonium bromide

1

Part 67 in the series ‘Studies on novel synthetic methodologies'; IICT Communication no. 051101.