PAPER	Synthesis 2006: 1652-1656   DOI: 10.1055/s-2006-926429
© Georg Thieme Verlag Stuttgart · New York
Efficient Microwave-Assisted Solvent-Free Synthesis of N-Substituted Aldimines
Ludovic Paquin, Jack Hamelin, Françoise Texier-Boullet*
Synthèse et Electrosynthèse organique 3, UMR 6510, CNRS et Université de Rennes 1, Campus de Beaulieu, 35042 Rennes, France Fax: +33(2)23236374; e-Mail: francoise.texier@univ-rennes1.fr;
Received 8 September 2005

Abstract

Neat non-volatile amines react with various aromatic aldehydes in the absence of any catalyst, solid support, or solvent, to give imines after a reaction time of eight minutes under microwave irradiation by a clean and very efficient process (yields: 75-100%). In the case of volatile amine, methylamine, 1,3-dimethylurea dispersed on montmorillonite K10 is used as an amine precursor to prepare the corresponding imines.

Key words

solvent-free reactions - microwave activation - N-substituted imines - ureas