PAPER	Synthesis 2006: 1635-1638   DOI: 10.1055/s-2006-926440
© Georg Thieme Verlag Stuttgart · New York
Simple Preparation of O-Substituted Hydroxylamines from Alcohols
Sébastien Albrecht, Albert Defoin*, Céline Tarnus
Laboratoire de Chimie Organique et Bioorganique, UMR 7015, École Nationale Supérieure de Chimie de Mulhouse, Université de Haute-Alsace, 3 rue Alfred Werner, 68093 Mulhouse Cédex, France Fax: +33(3)89336875 ; e-Mail: A.Defoin@uha.fr;
Received 23 December 2005

Abstract

A direct preparation of O-substituted hydroxylamines from alcohols is described by O-alkylation of tert-butyl N-hydroxy­carbamate with the methanesulfonates of respective alcohols, followed by acidic N-deprotection.

Key words

amination - nucleophilic substitution - hydroxylamine