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Letter
| Planta Med 2006; 72: 665-666
DOI: 10.1055/s-2006-931576 |
© Georg Thieme Verlag KG Stuttgart · New York |
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Aeruginascin, a Trimethylammonium Analogue of Psilocybin from the Hallucinogenic Mushroom Inocybe aeruginascens |
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| Niels Jensen1, Jochen Gartz2, Hartmut Laatsch1 |
1 Institute of Organic and Biomolecular Chemistry, Georg-August University Göttingen, Göttingen, Germany
2 Fungal Biotransformations, Leipzig, Germany |
Dedicated to Dr. Albert Hofmann in honour of his 100th birthday
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Abstract
The hallucinogenic mushroom Inocybe aeruginascens contains several typical Psilocybe alkaloids including psilocybin. We have now elucidated the structure of a further indole derivative named aeruginascin as the quaternary ammonium compound N,N,N-trimethyl-4-phosphoryloxytryptamine. Aeruginascin is closely related to the frog skin toxin bufotenidine (5-HTQ), a potent 5-HT3 receptor agonist, and has been found exclusively in Inocybe aeruginascens so far.
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