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| LETTER | Synlett 2006: 1165-1168
DOI: 10.1055/s-2006-932474 |
© Georg Thieme Verlag Stuttgart · New York
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A Mild and Efficient Desilylation of O-tert-Butyldimethylsilyl Ethers Mediated by Chlorotrimethylsilane and Potassium Fluoride Dihydrate in Acetonitrile
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| Yu Peng, Wei-Dong Z. Li* |
State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. of China
Fax: +86(931)8912539; e-Mail: liwd@lzu.edu.cn; e-Mail: isoc@lzu.edu.cn;
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Received
5 October 2005 |
Abstract
Desilylation of O-tert-butyldimethylsilyl ethers was achieved by a reagent system consisting of chlorotrimethylsilane and potassium fluoride dihydrate in acetonitrile. This alternative desilylation procedure is chemoselective, generally effective and operationally simple, and should find practical applications in organic synthesis. Key words
desilylation - potassium fluoride - chlorotrimethylsilane - O-tert-butyldimethylsilyl ether
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