SHORTPAPER	Synthesis 2006: 1931-1933   DOI: 10.1055/s-2006-942389
© Georg Thieme Verlag Stuttgart · New York
Useful Reagents for Introduction of Boc and Fmoc Protective Groups to Amines­: Boc-DMT and Fmoc-DMT
Kazuhito Hiokia,b, Mizuho Kinugasaa, Michiko Kishimotoa, Miho Fujiwaraa, Shohei Tania,b, Munetaka Kunishima*a,b
a Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Nishiku, Kobe 651-2180, Japan b High Technology Research Center, Kobe Gakuin University, Nishiku, Kobe 651-2180, Japan Fax: +81(78)9745689; e-Mail: kunisima@pharm.kobegakuin.ac.jp;
Received 6 January 2006

Abstract

New amino-protecting reagents, Boc-DMT and Fmoc-DMT, were prepared, and found to be useful for the introduction of Boc and Fmoc groups into amines. Both the reagents can protect various amines including amino acids in good yield in aqueous media. Since the reagents are neither unstable nor irritating, they are practically useful.

Key words

protecting groups - amines - amino acids - triazine - active carbonate ester