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| PAPER | Synthesis 2006: 2760-2766
DOI: 10.1055/s-2006-942488 |
© Georg Thieme Verlag Stuttgart · New York
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A New, Simple Synthesis of N-Tosyl Pyrrolidines and Piperidines
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| Maria Carla Marcotullio*a, Valerio Campagnaa, Silvia Sternativoa, Ferdinando Costantinob, Massimo Curinia |
a Dipartimento di Chimica e Tecnologia del Farmaco, Sez, Chimica Organica-Università degli Studi, 06123 Perugia, Italy
Fax: +39(075)5855116; e-Mail: marcotu@unipg.it;
b Dipartimento di Chimica-Università degli Studi, 06123 Perugia, Italy
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Received
25 January 2006 |
Abstract
Iodocyclization of unsaturated tosylamides promoted by Oxone® oxidation of KI afforded, in good yields, N-tosyl iodopyrrolidines and piperidines. A new, simple method for the conversion of alcohols to tosylamides is presented. Key words
pyrrolidines - piperidines - Oxone® - iodocyclization - toluenesulfonamides
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