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| LETTER | Synlett 2006: 1765-1767
DOI: 10.1055/s-2006-944200 |
© Georg Thieme Verlag Stuttgart · New York
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A Novel, One-Pot, Three-Component Synthesis of 1,2,4-Oxadiazoles under Microwave Irradiation and Solvent-Free Conditions
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| Mehdi Adib*a, Mohammad Mahdavia, Niusha Mahmoodia, Hooshang Pirelahia, Hamid Reza Bijanzadehb |
a School of Chemistry, University College of Science, University of Tehran, Tehran, Iran
Fax: +98(21)66495291; e-Mail: madib@khayam.ut.ac.ir;
b Department of Chemistry, Tarbiat Modarres University, Tehran, Iran
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Received
19 February 2006 |
Abstract
A novel synthesis of 3,5-disubstituted 1,2,4-oxadiazoles is described from a one-pot, three-component reaction between nitriles, hydroxylamine, and Meldrum's acids under microwave irradiation and solvent-free conditions in good to excellent yields. Key words
Meldrum's acids - nitriles - 1,2,4-oxadiazoles - three-component reaction - solvent-free synthesis
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