LETTER	Synlett 2006: 1756-1758   DOI: 10.1055/s-2006-944208
© Georg Thieme Verlag Stuttgart · New York
Iodine as an Efficient Catalyst for One-Pot Multicomponent Synthesis of β-Acetamido Ketones [1]
Biswanath Das*, K. Ravinder Reddy, R. Ramu, P. Thirupathi, B. Ravikanth
Organic Chemistry Division I, Indian Institute of Chemical Technology, Hyderabad - 500 007, India Fax: +91(40)27160512; e-Mail: biswanathdas@yahoo.com;
Received 10 February 2006

Abstract

Iodine efficiently catalyzes the three-component coupling of aromatic aldehydes, enolizable ketones or keto esters, and acetonitrile in the presence of acetyl chloride to afford β-acetamido ketones in good yields at room temperature.

Key words

β-acetamido ketone - iodine - multicomponent reaction

1

Part 85 in the series,‘Studies on Novel Synthetic Methodologies'. IICT Communication No. 03336.