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| LETTER | Synlett 2006: 2287-2289
DOI: 10.1055/s-2006-948207 |
© Georg Thieme Verlag Stuttgart · New York
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Chemoselective Bromination of Active Methylene and Methyne Compounds by Potassium Bromide, Hydrochloric Acid and Hydrogen Peroxide
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| Masayuki Kirihara*a, Shiho Ogawaa, Takuya Noguchia,b, Kumiko Okuboa, Yoshinari Monmac, Ikuko Shimizuc, Ryuji Shimosakic, Akihiko Hatanoa, Yoshiro Hirai*b |
a Department of Materials and Life Science, Shizuoka Institute of Science and Technology, 2200-2 Toyosawa, Fukuroi, Shizuoka 437-8555, Japan
Fax: +81(538)450110; e-Mail: kirihara@ms.sist.ac.jp;
b Faculty of Science, Department of Chemistry, Toyama University, 3190 Gofuku, Toyama 930-8555, Japan
c Konica Minolta Chemical Co. Ltd., 6909-9 Oono, Fukuroi, Shizuoka 437-1112, Japan
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Received
15 May 2006 |
Abstract
Active methylene and methyne compounds can be chemoselectively brominated in high yields using potassium bromide, hydrochloric acid, and hydrogen peroxide at room temperature. Key words
halogenation - halaides - green chemistry - bromination - active methylene compounds
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