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| LETTER | Synlett 2006: 2104-2108
DOI: 10.1055/s-2006-949609 |
© Georg Thieme Verlag Stuttgart · New York
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The First Simple Method of Protection of Hydroxy Compounds as their O-Boc Derivatives under Lewis Acid Catalysis
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| Giuseppe Bartoli*a, Marcella Boscoa, Armando Carlonea, Renato Dalpozzob, Manuela Locatellia, Paolo Melchiorrea, Paolo Palazzia, Letizia Sambria |
a Dipartimento di Chimica Organica ‘A. Mangini', Università di Bologna, viale Risorgimento 4, 40136 Bologna, Italy
Fax: +39(051)2093654; e-Mail: giuseppe.bartoli@unibo.it;
b Dipartimento di Chimica, Università della Calabria, Ponte Bucci, cubo 12C, 87036 Arcavacata di Rende (Cs), Italy
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Received
12 April 2006 |
Abstract
The first Lewis acid catalyzed protection of alcohols as Boc derivatives is described. Zinc acetate is a very efficient catalyst for this transformation and the reaction can be applied to primary, secondary and aromatic alcohols, providing the first example of a generally applicable method. Key words
alcohols - esterification - protecting groups - Lewis acids - zinc acetate
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