LETTER	Synlett 2006: 2203-2206   DOI: 10.1055/s-2006-949644
© Georg Thieme Verlag Stuttgart · New York
Modified Bucherer-Bergs Reaction for the One-Pot Synthesis of 5,5′-Disubstituted Hydantoins from Nitriles and Organometallic Reagents
Cyril Montagne, Michael Shipman*
Department of Chemistry, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK Fax: +44(24)76524429; e-Mail: m.shipman@warwick.ac.uk;
Received 21 April 2006

Abstract

Diverse sets of 5,5′-disubstituted hydantoins can conveniently be made in moderate to good yields (40-92%) by a one-pot process involving treatment of aromatic, heteroaromatic or aliphatic nitriles with an organometallic reagent (RLi or RMgX) followed by KCN/(NH₄)₂CO₃.

Key words

heterocycles - multicomponent reactions - combinatorial chemistry