PAPER	Synthesis 2006: 2996-3002   DOI: 10.1055/s-2006-950198
© Georg Thieme Verlag Stuttgart · New York
Efficient Oxidative Synthesis of 2-Oxazolines
Kirsten Schwekendiek, Frank Glorius*
Fachbereich Chemie, Philipps-Universität Marburg, Hans-Meerwein-Straße, 35032 Marburg, Germany Fax: +49(6421)2825629; e-Mail: glorius@chemie.uni-marburg.de;
Received 02 June 2006

Abstract

New methodology for the synthesis of variously substituted 2-oxazolines and one dihydrooxazine using aldehydes, amino alcohols, and N-bromosuccinimide as an oxidizing agent is described. This one-pot synthesis is characterized by mild reaction conditions, broad scope, high yields, and its preparative simplicity.

Key words

amino alcohols - oxidative coupling - oxazolines - oxazolidines - N-bromosuccinimide