PAPER	Synthesis 2006: 4131-4134   DOI: 10.1055/s-2006-950353
© Georg Thieme Verlag Stuttgart · New York
Sulfonyl Chloride Formation from Thiol Derivatives by N-Chlorosuccinimide Mediated Oxidation
Atsuko Nishiguchi*, Kazuhiro Maeda, Shokyo Miki
Chemical Development Laboratories, Takeda Pharmaceutical Company Limited, 2-17-85 Jusohonmachi, Yodogawa-ku, Osaka 532-8686, Japan Fax: +81(6)63006251; e-Mail: Nishiguchi_Atsuko@takeda.co.jp;
Received 14 June 2006

Abstract

Oxidation of several thiol derivatives by a combination of N-chlorosuccinimide and dilute hydrochloric acid proceeded smoothly, affording the corresponding sulfonyl chlorides in good yield.

Key words

thiol derivatives - oxidation - solvent effects - NCS - chlorosulfonation