LETTER	Synlett 2006: 2667-2669   DOI: 10.1055/s-2006-951485
© Georg Thieme Verlag Stuttgart · New York
A Modified U-4CR Reaction with 2-Nitrobenzylamine as an Ammonia Equivalent
Kuangsen Sung*, Fu-Lin Chen, Pei-Chun Huang
Department of Chemistry, National Cheng Kung University, Tainan, Taiwan Fax: +886(6)2740552; e-Mail: kssung@mail.ncku.edu.tw;
Received 19 July 2006

Abstract

A modified U-4CR reaction has been done by using commercially available 2-nitrobenzylamine as an ammonia equivalent and it involves a multi-component reaction, followed by photochemical cleavage of the 2-nitrobenzyl group, which can be done in one pot with good yields.

Key words

multicomponent reaction - photochemistry - peptides - isocyanide - ammonia equivalent