LETTER	Synlett 2006: 3017-3020   DOI: 10.1055/s-2006-951494
© Georg Thieme Verlag Stuttgart · New York
Conjugate Reduction of α,β-Unsaturated Carbonyl Compounds Promoted by Nickel Nanoparticles
Francisco Alonso, Iñaki Osante, Miguel Yus*
Departamento de Química Orgánica, Facultad de Ciencias and Instituto de Química Orgánica (ISO), Universidad de Alicante, Apdo 99, 03080 Alicante, Spain Fax: +34(965)903549; e-Mail: yus@ua.es;
Received 27 March 2006

Abstract

The system composed of nickel(II) chloride, lithium metal, a catalytic polymer-supported arene, and ethanol, has been efficiently applied to the conjugate reduction of a variety of α,β-unsaturated carbonyl compounds (ketones and carboxylic acid derivatives) under very mild reaction conditions.

Key words

conjugate reduction - ketones - carboxylic acid derivatives - nickel - nanoparticles