LETTER	Synlett 2007: 0131-0135   DOI: 10.1055/s-2006-958428
© Georg Thieme Verlag Stuttgart · New York
Simple and Efficient Microwave-Assisted Hydrogenation Reactions at ­Moderate Temperature and Pressure
Grace S. Vanier*
Life Science Division, CEM Corporation, P.O. Box 200, Matthews, NC 28106-0200, USA Fax: +1(704)8217894; e-Mail: grace.vanier@cem.com;
Received 15 August 2006

Abstract

A generally applicable method for the introduction of gaseous hydrogen into a sealed reaction system to perform hydrogenation reactions under microwave irradiation has been developed. Several different types of substrates are easily reduced in short reaction times with moderate temperatures between 80 °C and 100 °C with 50 psi of hydrogen. The use of simultaneous cooling is also applied to the hydrogenation of more difficult substrates.

Key words

hydrogenations - microwave - palladium - reductions - ­simultaneous cooling