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| PAPER | Synthesis 2007: 393-399
DOI: 10.1055/s-2007-965883 |
© Georg Thieme Verlag Stuttgart · New York
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Pd(N,N-Dimethyl β-alaninate)2 as a High-Turnover-Number, Phosphine-Free Catalyst for the Suzuki Reaction
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| Xin Cui, Tian Qin, Jia-Rui Wang, Lei Liu*, Qing-Xiang Guo* |
Department of Chemistry, University of Science and Technology of China, Hefei 230026, P. R. of China
e-Mail: leiliu@ustc.edu; e-Mail: qxguo@ustc.edu.cn;
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Received
25 August 2006 |
Abstract
A novel crystalline, air- and moisture-stable Pd salt, Pd(N,N-dimethyl β-alaninate)2, was synthesized. This salt was demonstrated to constitute a low-priced, phosphine-free, yet high-turnover-number (TON = 104) catalyst for the Suzuki reactions of various aryl bromides and iodides under mild and simple reaction conditions. Moreover, it was observed that the presence of an olefin could dramatically hamper the Suzuki reaction. Key words
palladium - Suzuki reaction - phosphine-free ligand - high-turnover-number catalyst
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