SHORTPAPER	Synthesis 2007: 666-668   DOI: 10.1055/s-2007-965921
© Georg Thieme Verlag Stuttgart · New York
Catalyst-Free Highly Regio- and Stereoselective Ring Opening of Epoxides and Aziridines with Sodium Azide Using Poly(ethylene glycol) as an Efficient Reaction Medium [1]
Biswanath Das*, Vtukuri Saidi Reddy, Fouzia Tehseen, Maddeboina Krishnaiah
Organic Chemistry Division - I, Indian Institute of Chemical Technology, Hyderabad 500 007, India Fax: +91(40)7160512; e-Mail: biswanathdas@yahoo.com;
Received 10 November 2006

Abstract

Ring opening of epoxides and aziridines has readily been carried out at room temperature using poly(ethylene glycol) (PEG-400) as the efficient reaction medium to form the corresponding 2-azido alcohols and 2-azido amines, respectively, in excellent yields (95-99%) within 30-45 minutes and with high regio- and streoselectivity.

Key words

epoxide - aziridine - PEG-400 - 2-azido alcohol - 2-azido amine

1

Part 103 in the series ‘Studies on Novel Synthetic Methodologies'; IICT Communication no. 061206.