PAPER	Synthesis 2007: 1061-1069   DOI: 10.1055/s-2007-965952
© Georg Thieme Verlag Stuttgart · New York
Synthesis of Substituted 2,2′-Bipyridines from 2-Bromo- or 2-Chloropyridines Using Tetrakis(triphenylphosphine)palladium(0) as a Catalyst in a Modified Negishi Cross-Coupling Reaction
U. Kiehne, J. Bunzen, H. Staats, A. Lützen*
University of Bonn, Kekulé-Institute of Organic Chemistry and Biochemistry, Gerhard-Domagk-Str. 1, 53121 Bonn, Germany Fax: +49(228)739608; e-Mail: arne.luetzen@uni-bonn.de;
Received 4 January 2007

Abstract

A protocol for an efficient, modified Negishi cross-coupling­ strategy for substituted 2,2′-bipyridines employing tetrakis(triphenylphosphine)palladium(0) as a simple, commercially available, and relatively inexpensive catalyst for both 2-bromo- and 2-chloropyridines has been developed. Further transformations were carried out yielding some new valuable functionalized 2,2′-bipyridines.

Key words

Negishi reaction - 2,2′-bipyridines - cross-coupling reactions - organozinc compounds - palladium