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| SPECIALTOPIC | Synthesis 2007: 1242-1246
DOI: 10.1055/s-2007-965980 |
© Georg Thieme Verlag Stuttgart · New York
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Synthesis of Pyrroles via Copper-Catalyzed Coupling of Amines with Bromoenones
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| Yuanjia Panb, Hongjian Lua, Yewen Fanga, Xinqiang Fanga, Liqun Chena, Junlu Qianb, Junhua Wanga, Chaozhong Li*a,b |
a Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, P. R. of China
Fax: +86(21)54925099; e-Mail: clig@mail.sioc.ac.cn;
b Department of Chemistry, Tongji University, 1239 Siping Road, Shanghai 200092, P. R. of China
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Received
7 February 2007 |
Abstract
The CuI/N,N-dimethylglycine hydrochloride catalyzed reactions of amines with γ-bromo-substituted γ,δ-unsaturated ketones in the presence of K3PO4 and NH4OAc led to the formation of the corresponding polysubstituted pyrroles in good to excellent yields. Key words
Ullmann-type reaction - amine - pyrrole - ammonium acetate
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