Letter Pharmacology	Planta Med 2007; 73: 363-365 DOI: 10.1055/s-2007-967128
© Georg Thieme Verlag KG Stuttgart · New York
Two Major Urinary Metabolites of Scutellarin in Rats
Feng Qiu1, HongJun Xia1, TieYing Zhang1, Xin Di2, GeXia Qu1, XinSheng Yao1
1 Department of Natural Products Chemistry, Shenyang Pharmaceutical University, Shenyang, Liaoning, P. R. China 2 Laboratory of Drug Metabolism and Pharmacokinetics, Shenyang Pharmaceutical University, Shenyang, Liaoning, P. R. China

Abstract

Urinary metabolites of scutellarin, the main effective constituent of breviscapine, a cerebrovascular and cardiovascular drug consisting of total flavonoids of Erigeron breviscapus, were investigated in rats. Two major metabolites were isolated from the urine of rats following oral administration of scutellarin and identified as scutellarein 6,7-di-O-β-D-glucuronide (M1) and scutellarein (M2), respectively, on the basis of chemical and spectroscopic evidence. M1 was reported as a metabolite of scutellarin for the first time.